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Clinical oncology

Section edited by: Prof Serigne Magueye Gueye and Prof Jan Vermorken. 

The clinical oncology section represents an opportunity to share experiences and information among worldwide oncologists and to identify and develop diagnostic as well as therapeutic protocols, which are globally valid in the current global village. Potential topics include, but are not limited to: epidemiology, pathology and pathogenesis of cancers and clinical studies

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  1. Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology.

    Authors: Martina Taborelli, Jerry Polesel, Maurizio Montella, Massimo Libra, Rosamaria Tedeschi, Monica Battiston, Michele Spina, Francesco Di Raimondo, Antonio Pinto, Anna Crispo, Maria Grimaldi, Silvia Franceschi, Luigino Dal Maso and Diego Serraino

    Citation: Infectious Agents and Cancer 2016 11:27

    Content type: Research Article

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  2. Prostate cancer is the most common cancer among men in Western countries but the exact pathogenic mechanism of the disease is still largely unknown. An infectious etiology and infection-induced inflammation ha...

    Authors: Sabina Davidsson, Paula Mölling, Jennifer R. Rider, Magnus Unemo, Mats G. Karlsson, Jessica Carlsson, Swen-Olof Andersson, Fredrik Elgh, Bo Söderquist and Ove Andrén

    Citation: Infectious Agents and Cancer 2016 11:26

    Content type: Research Article

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    The Erratum to this article has been published in Infectious Agents and Cancer 2016 11:36

  3. Intravesical instillation of bacille Calmette-Guérin (BCG) has been established as efficient therapy for superficial bladder carcinoma. Overall, intravesical BCG is well tolerated and results in complications ...

    Authors: C. Colomba, P. Di Carlo, G. Guadagnino, L. Siracusa, M. Trizzino, C. Gioè and A. Cascio

    Citation: Infectious Agents and Cancer 2016 11:25

    Content type: Short Report

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  4. The association between high risk human papillomaviruses (HPV) and cervical cancer has been firmly established. HPV genome is present in nearly all cases of cervical cancer and detection of viral DNA could the...

    Authors: Marianna Tortora, Clorinda Annunziata, Giuseppina Liguori, Simona Losito, Gerardo Botti, Stefano Greggi, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

    Citation: Infectious Agents and Cancer 2016 11:22

    Content type: Research Article

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  5. Human papillomavirus (HPV) prevalence in head and neck squamous cell carcinomas (HNSCC) diverges geographically. The reliability of using p16INK4a expression as a marker of viral infection is controversial in HNS...

    Authors: Julio C. Betiol, Laura Sichero, Henrique O. de Olival Costa, Leandro L. de Matos, Maria A. Andreoli, Silvaneide Ferreira, Sheila F. Faraj, Evandro S. de Mello, João S. Sobrinho, Lenine G. Brandão, Claudio R. Cernea, Marco A. Kulcsar, Fabio R. Pinto, Antonio J. Gonçalves, Marcelo B. Menezes, Leonardo Silva…

    Citation: Infectious Agents and Cancer 2016 11:20

    Content type: Research Article

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  6. Human papilloma virus (HPV) is a known causative factor in oropharyngeal squamous cell cancer (OPC). In this prospective study, we sought to define the risk of HPV transmission between OPC patients and their s...

    Authors: Anne S. Tsao, Vassiliki Papadimitrakopoulou, Heather Lin, Ming Guo, J. Jack Lee, F. Christopher Holsinger, Waun Ki Hong and Erich M. Sturgis

    Citation: Infectious Agents and Cancer 2016 11:21

    Content type: Research Article

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  7. This article evaluates a single institute’s radiotherapy management of OSSN, a previously regarded as rare malignancy, for possible future development of strategies to clearly define the role of adjuvant radio...

    Authors: Ntokozo Ndlovu, Sandra Ndarukwa, Webster Kadzatsa and Simbarashe Rusakaniko

    Citation: Infectious Agents and Cancer 2016 11:18

    Content type: Research Article

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  8. p16INK4A expression has been used as a surrogate marker for human papillomavirus (HPV) infection in cervical cancer and head and neck cancer. p53 has also been reported as a feasible marker to identify HPV-positi...

    Authors: Lianghai Wang, Jing Li, Jun Hou, Man Li, Xiaobin Cui, Shugang Li, Xiaodan Yu, Zhiyu Zhang, Weihua Liang, Jinfang Jiang, Lijuan Pang, Yunzhao Chen, Jin Zhao and Feng Li

    Citation: Infectious Agents and Cancer 2016 11:19

    Content type: Research Article

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  9. The association of human papillomavirus (HPV) types to neoplastic lesions increase as a function of their oncogenicity and the duration of the infection since lesion severity progresses from low-grade to high-...

    Authors: Raúl DelaRosa-Martínez, Mireya Sánchez-Garza and Rubén López-Revilla

    Citation: Infectious Agents and Cancer 2016 11:16

    Content type: Research Article

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  10. Organized cervical cancer screening services are presently lacking in Nigeria contributing to late presentation and diagnosis of invasive cervical cancer cases (ICCs) at advanced stages in most gynecologic uni...

    Authors: Jonah Musa, Joseph Nankat, Chad J. Achenbach, Iornum H. Shambe, Babafemi O. Taiwo, Barnabas Mandong, Patrick H. Daru, Robert L. Murphy and Atiene S. Sagay

    Citation: Infectious Agents and Cancer 2016 11:15

    Content type: Research Article

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  11. Insulin resistance is considered to be an important factor in the progression of fibrosis and the enhancement of the risk of hepatocellular carcinoma (HCC) for chronic hepatitis C patients. The aim of this stu...

    Authors: Takeo Hayashi, Eiichi Ogawa, Norihiro Furusyo, Masayuki Murata and Jun Hayashi

    Citation: Infectious Agents and Cancer 2016 11:9

    Content type: Research Article

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  12. We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseli...

    Authors: Anna Maria Cattelan, Adriana Mattiolo, Angela Grassi, Maria Assunta Piano, Lolita Sasset, Marco Trevenzoli, Paola Zanovello and Maria Luisa Calabrò

    Citation: Infectious Agents and Cancer 2016 11:5

    Content type: Short Report

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  13. Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas g...

    Authors: Shegan Gao, Shuoguo Li, Zhikun Ma, Shuo Liang, Tanyou Shan, Mengxi Zhang, Xiaojuan Zhu, Pengfei Zhang, Gang Liu, Fuyou Zhou, Xiang Yuan, Ruinuo Jia, Jan Potempa, David A. Scott, Richard J. Lamont, Huizhi Wang…

    Citation: Infectious Agents and Cancer 2016 11:3

    Content type: Research Article

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  14. Human Papillomavirus (HPV) is well known pathogen that can cause benign and malignant tumors in humans, yet there is very little information regarding HPV types prevalent in Pakistan.

    Authors: Abdullah Abdullah, Muhammad Qasim, Muhammad Shafiq, Muhammad Ijaz, Shamsa Parveen, Shahnaz Murtaza, Qamar Javed, Salman Akbar Malik, Shahida Husain Tarar, Sajid Mehmood, Abdul Sami, Syed Muhammad Saqlan Naqvi and Muhammad Zeeshan Hyder

    Citation: Infectious Agents and Cancer 2016 11:1

    Content type: Research Article

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  15. Simple epithelial keratins appear early during embryonic development and are expressed in non-stratified, ductal and pseudo-stratified epithelial tissues. CK19, the lowest molecular weight keratin, is also exp...

    Authors: Angela Santoro, Giuseppe Pannone, Rossella Ninivaggi, Massimo Petruzzi, Andrea Santarelli, Giuseppe Maria Russo, Silvia Lepore, Michele Pietrafesa, Ilaria Laurenzana, Rosalia Leonardi, Paolo Bucci, Maria Iole Natalicchio, Alberta Lucchese, Silvana Papagerakis and Pantaleo Bufo

    Citation: Infectious Agents and Cancer 2015 10:46

    Content type: Research Article

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  16. Cytomegalovirus reactivation can be life threatening. However, little evidence on its incidence in solid cancers is available. Therefore our single center Cytomegalovirus polymerase chain reaction database wit...

    Authors: Konstantin Schlick, Michael Grundbichler, Jutta Auberger, Jan Marco Kern, Markus Hell, Florian Hohla, Georg Hopfinger and Richard Greil

    Citation: Infectious Agents and Cancer 2015 10:45

    Content type: Short Report

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  17. We previously conducted a population-based screening trial of high-risk human papillomavirus (hrHPV) testing and conventional cytology, demonstrating higher sensitivity (92.7 % vs 22.1 % for CIN2+) but lower p...

    Authors: Marcela Lagos, Vanessa Van De Wyngard, Helena Poggi, Paz Cook, Paola Viviani, María Isabel Barriga, Martha Pruyas and Catterina Ferreccio

    Citation: Infectious Agents and Cancer 2015 10:43

    Content type: Research Article

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  18. The main objective of our study was to evaluate the colposcopist ability to correctly identify the worst area of a cervical lesion where biopsy should be performed; the secondary objective was to investigate t...

    Authors: Giuseppe Bifulco, Nicoletta De Rosa, Giada Lavitola, Roberto Piccoli, Alessandra Bertrando, Valentina Natella, Costantino Di Carlo, Luigi Insabato and Carmine Nappi

    Citation: Infectious Agents and Cancer 2015 10:47

    Content type: Research Article

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  19. Although the inclusion of the HPV vaccine has been registered in Spain since 2007, vaccination rates are lower than expected. The patients wish to be vaccinated is heavily influenced by information they have r...

    Authors: M. Reyes Oliver Pérez, Victoria Bravo Violeta, Ana Vazquez del Campo, Cristina Ruiz, Sonia Yáñez Castaño, Laura P. Pérez Conde and Jesús S. Jiménez López

    Citation: Infectious Agents and Cancer 2015 10:41

    Content type: Research Article

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  20. The association between HIV viremia and non-AIDS-defining cancers (NADCs) is not well characterized. Viremia may contribute directly or indirectly to cancer development and may have a differential impact on va...

    Authors: David J. Riedel, Anne F. Rositch and Robert R. Redfield

    Citation: Infectious Agents and Cancer 2015 10:38

    Content type: Short Report

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  21. Epidemiological studies have examined the association between human papillomavirus (HPV) and breast cancer, but the findings are inconclusive. This study aimed to detect the prevalence of HPV in breast cancer ...

    Authors: Yi Zhou, Jinyuan Li, Yuting Ji, Ming Ren, Bo Pang, Ming Chu and Lanlan Wei

    Citation: Infectious Agents and Cancer 2015 10:36

    Content type: Research Article

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  22. The role of Merkel cell polyomavirus (MCV) infection in the etiology of non-melanoma skin cancers, other than Merkel cell carcinoma, is unclear. Previously, we reported a significant association between seropo...

    Authors: Shalaka S. Hampras, Angelika Michel, Markus Schmitt, Tim Waterboer, Lena Kranz, Tarik Gheit, Kate Fisher, Vernon K. Sondak, Jane Messina, Neil Fenske, Basil Cherpelis, Massimo Tommasino, Michael Pawlita and Dana E. Rollison

    Citation: Infectious Agents and Cancer 2015 10:35

    Content type: Short Report

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  23. The aim of this study was to analyze the prevalence of HPV and EBV in oral and oropharyngeal squamous cell carcinoma in south-eastern Poland. The correlation between viral infection, OSCC, alcohol use, tobacco...

    Authors: Dorota Polz-Gruszka, Kamal Morshed, Agnieszka Stec and Małgorzata Polz-Dacewicz

    Citation: Infectious Agents and Cancer 2015 10:37

    Content type: Research Article

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  24. The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), two low cost, routinely available inflammatory indices, have been found to be associated with risk of death in patients with sol...

    Authors: Elena Raffetti, Francesco Donato, Francesco Castelli, Franco Maggiolo, Giampiero Carosi and Eugenia Quiros-Roldan

    Citation: Infectious Agents and Cancer 2015 10:34

    Content type: Research Article

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  25. Viral infections and the burden of high-grade intraepithelial neoplasias (HIN) and invasive carcinomas (IC) associated to infections by human papillomavirus (HPV) types may be prevented by type-specific anti-H...

    Authors: Claudia Magaña-León, Cuauhtémoc Oros and Rubén López-Revilla

    Citation: Infectious Agents and Cancer 2015 10:33

    Content type: Research Article

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    The Erratum to this article has been published in Infectious Agents and Cancer 2016 11:11

  26. Cat-scratch disease (CSD) is a common infection in children; however, the wide spectrum of its clinical picture may lead to delayed diagnosis. An unusual presentation of CSD includes in the differential diagno...

    Authors: Katarzyna Mazur-Melewska, Katarzyna Jończyk-Potoczna, Anna Mania, Paweł Kemnitz, Jarosław Szydłowski, Wojciech Służewski and Magdalena Figlerowicz

    Citation: Infectious Agents and Cancer 2015 10:30

    Content type: Research Article

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  27. Identification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. Therefore, the aim of this study was...

    Authors: Hussain Gadelkarim Ahmed, Saleh Hussein Bensumaidea and Ibraheem M. Ashankyty

    Citation: Infectious Agents and Cancer 2015 10:29

    Content type: Research Article

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  28. A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of hum...

    Authors: Hector Rodríguez, Jorge Levican, Juan P. Muñoz, Diego Carrillo, Mónica L. Acevedo, Aldo Gaggero, Oscar León, Tarik Gheit, Omar Espinoza-Navarro, Jorge Castillo, Iván Gallegos, Massimo Tommasino and Francisco Aguayo

    Citation: Infectious Agents and Cancer 2015 10:27

    Content type: Research Article

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  29. We aimed to clarify the possible role of human papillomavirus (HPV) infection in the malignant transformation of sinonasal inverted papilloma (IP).

    Authors: Yukashi Yamashita, Masahiro Hasegawa, Zeyi Deng, Hiroyuki Maeda, Shunsuke Kondo, Asanori Kyuna, Sen Matayoshi, Shinya Agena, Takayuki Uehara, Hideaki Kouzaki, Takeshi Shimizu, Taro Ikegami, Akira Ganaha and Mikio Suzuki

    Citation: Infectious Agents and Cancer 2015 10:23

    Content type: Research Article

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  30. Human pancreatic cancer is currently one of the deadliest cancers with high mortality rate. It has been previously shown that (−)-epigallocatechin-3-gallate (EGCG), the most abundant catechin found in green te...

    Authors: Sabrina Bimonte, Maddalena Leongito, Antonio Barbieri, Vitale Del Vecchio, Massimiliano Barbieri, Vittorio Albino, Mauro Piccirillo, Alfonso Amore, Raimondo Di Giacomo, Aurelio Nasto, Vincenza Granata, Antonella Petrillo, Claudio Arra and Francesco Izzo

    Citation: Infectious Agents and Cancer 2015 10:22

    Content type: Research Article

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  31. The prevalence of High-Risk Human papilloma virus (HR-HPV), a necessary cause of invasive cervical cancer (ICC) is relatively high in HIV infected women. Gaps exist in our knowledge of the optimal approaches f...

    Authors: Jonah Musa, Chad Achenbach, Babafemi Taiwo, Baiba Berzins, Olugbenga Silas, Patrick H Daru, Oche Agbaji, Godwin Imade, Atiene S Sagay, John A Idoko, Phyllis J Kanki and Robert L Murphy

    Citation: Infectious Agents and Cancer 2014 9:36

    Content type: Research article

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  32. The exact worldwide incidence of Burkitt’s lymphoma is not known. There are three distinct clinical variants of Burkitt’s lymphoma, each manifesting differences in epidemiology, clinical presentation, morpholo...

    Authors: Giuseppe Pannone, Rosanna Zamparese, Mirella Pace, Maria Carmela Pedicillo, Simona Cagiano, Pasquale Somma, Maria Elena Errico, Vittoria Donofrio, Renato Franco, Annarosaria De Chiara, Gabriella Aquino, Paolo Bucci, Eduardo Bucci, Angela Santoro and Pantaleo Bufo

    Citation: Infectious Agents and Cancer 2014 9:34

    Content type: Review

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  33. Oncoviruses such as HPV, KSHV, and EBV have been reported in patients with HIV infection and AIDS. How oncovirus-associated cancers rise in AIDS patients has not been fully established. The purpose of our stud...

    Authors: Kenneth O Simbiri, Hem C Jha, Mukendi K Kayembe, Carrie Kovarik and Erle S Robertson

    Citation: Infectious Agents and Cancer 2014 9:28

    Content type: Research article

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  34. The worldwide administration of bivalent and quadrivalent HPV vaccines has resulted in cross-protection against non-vaccine HPV types. Infection with multiple HPV types may offer similar cross-protection in th...

    Authors: Rafal S Sobota, Doreen Ramogola-Masire, Scott M Williams and Nicola M Zetola

    Citation: Infectious Agents and Cancer 2014 9:26

    Content type: Short report

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  35. Infection with urinary schistosomiasis and its severity are oncogenic factors for developing carcinoma of the bladder, whether it is urothelial carcinoma (UC) of a transitional cell type (TCC) or non-urothelia...

    Authors: Mohamed Wishahi, Ahmed Zakarya, Olfat Hamamm, Mohamed Abdel-Rasol, Hisham Badawy, Hossam Elganzoury, Mohamed Ismail, Amr Elkhouly and Ahmed Meheina

    Citation: Infectious Agents and Cancer 2014 9:21

    Content type: Research article

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  36. Case-controlled studies have clearly demonstrated a link between chronic hepatitis C infection (CHC) and B cell non-Hodgkin lymphoma (NHL). To our knowledge, this is the first case report of outcome in a patie...

    Authors: Stefan Christensen and Anton Gillessen

    Citation: Infectious Agents and Cancer 2014 9:10

    Content type: Short report

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  37. Breast cancer is the commonest cancer in Sudanese women. Reported genetic alterations in the form of mutations in tumor suppressors are low in frequencies and could not explain the peculiarities of the disease...

    Authors: Zeinab A Yahia, Ameera AM Adam, Magdeldin Elgizouli, Ayman Hussein, Mai A Masri, Mayada Kamal, Hiba S Mohamed, Kamal Alzaki, Ahmed M Elhassan, Kamal Hamad and Muntaser E Ibrahim

    Citation: Infectious Agents and Cancer 2014 9:9

    Content type: Research article

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  38. Squamous cell carcinoma of conjunctiva has increased tenfold in the era of HIV/AIDS. The disease pattern has also changed in Africa, affecting young persons, with peak age-specific incidence of 30-39 years, si...

    Authors: Anthony Mwololo, Joshua Nyagol, Emily Rogena, Willis Ochuk, Mary Kimani, Noel Onyango, Lorenzo Pacenti, Rosa Santopietro, Lorenzo Leoncini and Walter Mwanda

    Citation: Infectious Agents and Cancer 2014 9:7

    Content type: Research article

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  39. Human Papillomavirus (HPV) infection is particularly burdensome for women infected with human immunodeficiency virus (HIV), which increases their risk of developing cervical lesions and cancer (CC). We conducted ...

    Authors: Sheila C Rocha-Brischiliari, Fabrícia Gimenes, André L P de Abreu, Mary M T Irie, Raquel P Souza, Rosangela G Santana, Angela A F Gravena, Maria D de B Carvalho, Marcia E L Consolaro and Sandra M Pelloso

    Citation: Infectious Agents and Cancer 2014 9:6

    Content type: Short report

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  40. Colorectal cancers are the third most common type in the world. The causes of the disease are poorly understood, but since the discovery of Helicobacter pylori as a causative agent of gastric cancer, attention ha...

    Authors: Peter C Tyrer, Frank A Frizelle and Jacqueline I Keenan

    Citation: Infectious Agents and Cancer 2014 9:2

    Content type: Research article

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  41. Akt, better known as protein kinase B (PKB), is a serine/threonine-specific protein kinase which acts as mediator via PI3K/Akt pathway in many biological processes like glucose metabolism, apoptosis, cell diff...

    Authors: Jaikrit Bhutani, Asfandyar Sheikh and Asfandyar Khan Niazi

    Citation: Infectious Agents and Cancer 2013 8:49

    Content type: Letter to the Editor

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  42. Children with Down syndrome (DS) are at high risk of infectious toxicity when treated with acute lymphoblastic leukemia chemotherapy protocols optimized in children without DS. Our objective was to determine i...

    Authors: Thai Hoa Tran, David Mitchell, David Dix, Sonia Cellot, Marie-Chantal Ethier, Biljana Gillmeister, Johann Hitzler, Victor Lewis, Rochelle Yanofsky, Donna L Johnston, Carol Portwine, Victoria Price, Shayna Zelcer, Mariana Silva, Bruno Michon, Lynette Bowes…

    Citation: Infectious Agents and Cancer 2013 8:47

    Content type: Research article

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  43. Microsporidia are obligate intracellular opportunistic fungi that cause significant pathology in immunocompromised hosts. However, 11 percent of immunocompetent individuals in the general population are micros...

    Authors: Cory Ann Leonard, Maria Schell, Robert Vincent Schoborg and James Russell Hayman

    Citation: Infectious Agents and Cancer 2013 8:43

    Content type: Short report

    Published on:

  44. Among men in the U.S., prostate cancer is the most common cancer and the second leading cause of cancer death. Despite its prevalence, there are few established risk factors for prostate cancer. Some studies h...

    Authors: E Susan Amirian, Joseph F Petrosino, Nadim J Ajami, Yanhong Liu, Martha P Mims and Michael E Scheurer

    Citation: Infectious Agents and Cancer 2013 8:42

    Content type: Hypothesis

    Published on:

  45. This is a summary of the 1st Academic Model Providing Access to Healthcare (AMPATH) Oncology Institute research grant writing workshop organized in collaboration with the Kenya Medical Research Institute (KEMRI) ...

    Authors: Ann Moormann, Jodi Skiles, Emmanuel Koros, Fredrick Chite Asirwa, Naftali Busakhala and Patrick Loehrer

    Citation: Infectious Agents and Cancer 2013 8:40

    Content type: Meeting report

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