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Table 1 Clinical and pathological features of penile carcinomas in our series

From: Discrepancy of p16 immunohistochemical expression and HPV RNA in penile cancer. A multiplex in situ hybridization/immunohistochemistry approach study

   P16 IHC HPV ISH multiplex HPV RNA ISH /p16 IHC
  Total Positive
> 70 % N. (%) 		Negative
N. (%) 		Positive
N. (%) 		Negative
N. (%) 		P16+
ISH+
N. (%) 		P16+
ISH-
N. (%) 		P16-
ISH-
N. (%) 		P16-
ISH+
N. (%)
Mean age (years)
 < 60 28 (46.7 %) 14
(23.3 %) 		14
(23.3 %) 		6
(10 %) 		22
(36.7 %) 		6
(10 %) 		8
(13.3 %) 		14
(23.3 %) 		 
 ≥ 60 32 (53.3 %) 14
(23.3 %) 		18
(30 %) 		9
(15 %) 		23
(38.3 %) 		9
(15 %) 		5
(8.3 %) 		18
(30 %) 		 
Anatomical Location
 glans 54
(90 %) 		25
(46.3 %) 		29
(53.7 %) 		13
(24.1 %) 		41
(75.9 %) 		13
(24.1 %) 		12
(22.2 %) 		29
(53.7 %) 		 
 foreskin 3
(5 %) 		1
(1.7 %) 		2
(3.3 %) 		1
(1.7 %) 		2
(3.3 %) 		1
(1.7 %) 		  2
(3.3 %) 		 
 shaft 3
(5 %) 		2
(3.3 %) 		1
(1.7 %) 		1
(1.7 %) 		2
(3.3 %) 		1
(1.7 %) 		1
(1.7 %) 		1
(1.7 %) 		 
T stage
 T1 19
(31.7 %) 		9
(15 %) 		10
(16.7 %) 		4
(6.7 %) 		15
(25 %) 		4
(6.7 %) 		5
(8.3 %) 		10
(16.7 %) 		 
 T2 17
(28.3 %) 		5
(8.3 %) 		12
(20 %) 		1
(1.7 %) 		16
(26.7 %) 		1
(1.7 %) 		4
(6.7 %) 		12
(20 %) 		 
 T3 11
(18.3 %) 		6
(10 %) 		5
(8.3 %) 		4
(6.7 %) 		7
(11.7 %) 		4
(6.7 %) 		2
(3.3 %) 		5
(8.3 %) 		 
 T4 3
(5 %) 		1
(1.7 %) 		2
(3.3 %) 		1
(1.7 %) 		2
(3.3 %) 		1
(1.7 %) 		  2
(3.3 %) 		 
 in situ 2
(3.3 %) 		2
(3.3 %) 		  2
(3.3 %) 		  2
(3.3 %) 		   
 NA 8
(13.3 %) 		5
(8.3 %) 		3
(5 %) 		3
(5 %) 		5
(8.3 %) 		3
(5 %) 		2
(3.3 %) 		3
(5 %) 		 
Histological classification
 USCC 49
(81.7 %) 		19
(31.7 %) 		30
(50 %) 		9
(15 %) 		40
(66.7 %) 		9
(15 %) 		11
(18.3 %) 		29
(48.3 %) 		 
 papillary type 2
(3.3 %) 		2
(3.3 %) 		  1
(1.7 %) 		1
(1.7 %) 		1
(1.7 %) 		  1
(1.7 %) 		 
 verrucous 3
(5 %) 		1
(1.7 %) 		2
(3.3 %) 		1
(1.7 %) 		2
(3.3 %) 		1
(1.7 %) 		  2
(3.3 %) 		 
 basaloid 4
(6.7 %) 		4
(6.7 %) 		  2
(3.3 %) 		2
(3.3 %) 		2
(3.3 %) 		2
(3.3 %) 		  
 warty 1
(1.7 %) 		1
(1.7 %) 		  1
(1.7 %) 		  1
(1.7 %) 		   
 mixed
(warty-basaloid) 		1 (1.7 %) 1
(1.7 %) 		  1
(1.7 %) 		  1
(1.7 %) 		   
Histological grade
 G1 15
(25 %) 		7
(11.7 %) 		8
(13.3 %) 		2
(3.3 %) 		13
(21.7 %) 		2
(3.3 %) 		5
(8.3 %) 		8
(13.3 %) 		 
 G2 22
(36.7 %) 		7
(11.7 %) 		15
(25 %) 		2
(3.3 %) 		20
(33.3 %) 		2
(3.3 %) 		5
(8.3 %) 		15
(25 %) 		 
 G3 13
(21.7 %) 		7
(11.7 %) 		6
(10 %) 		6
(10 %) 		7
(11.7 %) 		6
(10 %) 		1
(1.7 %) 		6
(10 %) 		 
 NAP
(special types and in situ carcinomas) 		10
(16.7 %) 		7
(11.7 %) 		3
(5 %) 		5
(8.3 %) 		5
(8.3 %) 		5
(8.3 %) 		2
(3.3 %) 		3
(5 %) 		 
Total 60
(100 %) 		28
(46.7 %) 		32
(53.3 %) 		15
(25 %) 		45
(75 %) 		15
(25 %) 		13
(21.7 %) 		32
( 53.3 %) 		0
  1. USCC usual squamous cell carcinoma; NA not available; NAP not applicable
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