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Table 1 Protein patterns distinguishing different EBV states

From: Epstein-Barr virus BART microRNAs in EBV- associated Hodgkin lymphoma and gastric cancer

Cell typeEBV stateBZLF1BARF-1amiR-miR-EBNA proteins  LMP  
    BARTsBHRF1s123A3B3CLP12A2BEBER
Plasma cellLytic++++#+
PEL, NPC               
Memory B cellLatency 1+−/+++
Germinal center BLatency 2+−/+++++++
cell, HD, NPC, BL               
Naïve B cell, LCBLLatency 3++++++++++++
Gastric carcinomaLatency 1–2+++++++
  1. a BARF1 promoter is cell-type specific: in viral latency, BARF1 is exclusively expressed in epithelial tumors such as nasopharyngeal and gastric carcinoma but not in lymphoma. # miR-BHRF1s are restricted to lymphoblastoid cell lines (LCL) and nasal NK/T cell lymphoma. BARF and EBER, RNA; BL Burkitt lymphoma, DLCBL Diffuse large B-cell lymphoma; EBNA EBV nuclear antigen; HD Hodgkin disease; LMP Latent membrane proteins; NPC Nasopharyngeal carcinoma; PEL Reactivity of peripheral blood lymphocytes