Prevalence, correlates, and predictive value of high-risk human papillomavirus mRNA detection in a community-based cervical cancer screening program in western Uganda

Table 4 Positive predictive value, by self-reported HIV infection status, of detecting hrHPV E6/E7 mRNA for the presence of CIN 2+ among women from two rural districts of Uganda participating in a community-based study of cervical cancer screening

hrHPV Type Detected	HIV-infected^b Participants			HIV-uninfected Participants			HIV-untested Participants			All Participants
hrHPV Type Detected	Total No.	No. with CIN 2+	Positive predictive value % (95% CI)	Total No.	No. with CIN 2+	Positive predictive value % (95% CI)	Total No.	No. with CIN 2+	Positive predictive value % (95% CI)	Total No.	No. with CIN 2+	Positive predictive value% (95% CI)
Any hrHPV	42	4	9.8% (2.7 to 23%)	193	12	6.3% (3.3 to 11%)	20	5	25% (8.7 to 49%)	255	21	8.2% (5.1 to 12%)
At least one of HPV-16, 18 and 45^a	10	1	10% (0.25 to 45%)	43	4	9.5% (2.7 to 23%)	5	4	80% (28 to 99%)	58	9	15% (7.3 to 27%)
HPV-16^a	4	0	0% (0 to 60%)	28	3	11% (2.3 to 28%)	2	2	100% (16 to 100%)	34	5	15% (5.0 to 31%)
HPV-18 and/or 45^a	7	1	14% (0.36 to 58%)	16	1	6.3% (0.15 to 30%)	3	2	67% (9.4 to 99%)	26	4	15% (4.4 to 35%)
At least one of HPV-31, 33, 35, 39, 51, 52, 56, 58, 59, 66 and 68 but without 16, 18 and 45	32	3	9.1% (1.9 to 24%)	150	8	29% (22 to 37%)	15	1	13% (1.7 to 40%)	197	12	6.1% (3.2 to 10%)

ISSN: 1750-9378