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| |
OS
|
RFS
|
|---|
|
Variable
|
n
|
HR
|
95% CI
|
P value
|
HR
|
95% CI
|
P value
|
|---|
|
Sex (female vs male)
|
5 vs 34
|
1.179
|
0.345–4.031
|
0.792
|
1.016
|
0.229–4.509
|
0.984
|
|
Age years (≤52 vs >52)
|
21 vs 18
|
0.754
|
0.312–1.824
|
0.531
|
1.680
|
0.596–4.732
|
0.326
|
|
AFP (ng/ml; ≤20 vs >20)
|
13 vs 25
|
1.734
|
0.629–4.778
|
0.287
|
1.214
|
0.414–3.555
|
0.724
|
|
HBsAg (IU/mL; <1000 vs ≥1,000)
|
6 vs 28
|
5.915
|
0.784–44.637
|
0.085
|
1.561
|
0.340–7.179
|
0.567
|
|
HBeAg (negative vs positive)
|
33 vs 6
|
8.931
|
2.661–29.982
|
0.000
|
3.361
|
0.848–13.321
|
0.085
|
|
HBV-DNA (IU/mL; <1000 vs ≥1,000)
|
10 vs 9
|
7.798
|
1.580–38.496
|
0.012
|
2.808
|
0.647–12.186
|
0.168
|
|
HCV-Ab (S/CO; <10.9 vs ≥10.9)
|
8 vs 12
|
0.579
|
0.152–2.207
|
0.424
|
0.808
|
0.189–3.455
|
0.774
|
|
Liver cirrhosis (no vs yes)
|
13 vs 26
|
1.245
|
0.478–3.243
|
0.654
|
2.118
|
0.596–7.519
|
0.246
|
|
Tumor size (cm; ≤5 vs >5)
|
25 vs 14
|
4.336
|
1.753–10.722
|
0.001
|
2.302
|
0.793–6.686
|
0.125
|
|
Tumor number (single vs multiple)
|
31 vs 8
|
3.155
|
1.145–8.695
|
0.026
|
1.679
|
0.455–6.190
|
0.437
|
|
Vascular invasion (no vs yes)
|
26 vs 13
|
3.352
|
1.358–8.272
|
0.009
|
3.806
|
13.60–10.646
|
0.011
|
|
Capsule (no vs yes)
|
12 vs 26
|
1.319
|
0.474–3.670
|
0.596
|
0.775
|
0.259–2.317
|
0.648
|
|
Tumor differentiation (I-II vs III-IV)
|
21 vs 16
|
0.798
|
0.308–2.068
|
0.642
|
0.664
|
0.221–1.992
|
0.465
|
- Note: Univariate analysis, Cox proportional hazards regression model
- Abbreviations: HR, Hazard ratio; 95% CI, 95% confidence interval; AFP, alpha-fetoprotein; HCV-Ab, HCV antibody
